Übersichten

Cyclosporine for rheumatoid arthritis.
Wells G, Haguenauer D, Shea B, Suarez-Almazor ME, Welch VA, Tugwell P.
Department of Epidemiology and Community Medicine, University of Ottawa, 451 Smyth Road, Room 3227, Ottawa, Ontario, Canada, K1H 8M5.  gawells(at)sprint.ca
Cochrane Database Syst Rev. 2000;(2):CD001083
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Wirksamkeit von Immunosporin bei der Therapie der rheumatoiden Arthritis: Besserung der klinischen Symptome

A randomised double-blind trial of cyclosporin and azathioprine in refractory rheumatoid arthritis.
Ahern MJ, Harrison W, Hollingsworth P, Bradley J, Laing B, Bayliss C.
Department of Clinical Immunology, Flinders University of South Australia, Adelaide.
Aust N Z J Med. 1991 Dec;21(6):844-9.
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Comparison of cyclosporin A and azathioprine in the treatment of rheumatoid arthritis--results of a double-blind multicentre study.
Kruger K, Schattenkirchner M.
Rheumatology Unit, Ludwig Maximilians University Hospital, Munich, FRG.
Clin Rheumatol. 1994 Jun;13(2):248-55.
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Cyclosporine A in rheumatoid arthritis: randomized, placebo controlled dose finding study.
Altman RD, Schiff M, Kopp EJ.
University of Miami, Miami Veterans Affairs Medical Center, FL 33101, USA.
J Rheumatol. 1999 Oct;26(10):2102-9
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Klinische Studien zur neuen Mikroemulsions-Formulierung

Große Studien / Zulassungsrelevante Studien / Pivotal Studies

Microemulsion formulation of cyclosporin (Sandimmun Neoral) vs Sandimmun: comparative safety, tolerability and efficacy in severe active rheumatoid arthritis. On behalf of the OLR 302 Study Group.
Yocum DE, Allard S, Cohen SB, Emery P, Flipo RM, Goobar J, Jayawardena S, Job-Deslandre C, Jubb RW, Kruger K, Lopes Vaz A, Manger B, Mur E, Nygaard H, Weiner SM, Rainer F, Sack MR, Schiff MH, Schnitzer TJ, Trigg LB, Whatmough I, Schmidt AG.
Arizona Arthritis Center, University of Arizona, Tucson, Arizona, USA.
Rheumatology (Oxford). 2000 Feb;39(2):156-64.
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Safety and tolerability of conversion from stable Sandimmun maintenance treatment to Sandimmun Neoral in patients with rheumatoid arthritis.
Flipo RM, Emery P, Scott DG, Situnayake RD, Prowse PJ, James DW, Cawley MI, Whatmough I, Schmidt AG.
Department of Rheumatology, CHU, Lille, France.
J Rheumatol. 1998 Jul;25(7):1263-9.
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The safety and efficacy of cyclosporine (Neoral) in rheumatoid arthritis.
Johns KR, Littlejohn GO.
Department of Rheumatology/Centre for Inflammatory Diseases, Monash University, Clayton, Victoria, Australia.  Kathryn.Johns(at)med.monash.edu.au
J Rheumatol. 1999 Oct;26(10):2110-3
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Weitere, z.T. kleinere Studien

[Use of cyclosporin A in patients with severe, active, treatment-resistant rheumatoid arthritis ]
[Article in Spanish]
Reyes Salinas A, Rojas Ramos E, Martinez Jimenez N.
Departamento de Inmunologia Clinica y Reumatologia, Hospital Regional 1 de Octubre, ISSSTE, Mexico DF.
Rev Alerg Mex. 2002 Jul-Aug;49(4):116-20
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Wirksamkeit von Ciclosporin bei der frühen rheumatoiden Arthritis

A randomized, double-blind, 24-week controlled study of low-dose cyclosporine versus chloroquine for early rheumatoid arthritis.
Landewe RB, Goei The HS, van Rijthoven AW, Breedveld FC, Dijkmans BA.
Department of Rheumatology, University Hospital Leiden, The Netherlands.
Arthritis Rheum. 1994 May;37(5):637-43.
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Low dose cyclosporine in early rheumatoid arthritis: effective and safe after two years of therapy when compared with chloroquine.
van den Borne BE, Landewe RB, The HS, Breedveld FC, Dijkmans BA.
Department of Rheumatology, Leiden University Hospital, Wever Hospital Heerlen, The Netherlands.
Scand J Rheumatol. 1996;25(5):307-16
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Cyclosporine A in the treatment of early rheumatoid arthritis. A prospective, randomized 24-month study.
Drosos AA, Voulgari PV, Papadopoulos IA, Politi EN, Georgiou PE, Zikou AK.
Department of Internal Medicine, University of Ioannina, Medical School, Greece.
Clin Exp Rheumatol. 1998 Nov-Dec;16(6):695-701.
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Einfluß von Immunosporin auf die Röntgenprogression der rheumatoiden Arthritis

Radiologic evidence of disease modification in rheumatoid arthritis patients treated with cyclosporine. Results of a 48-week multicenter study comparing low-dose cyclosporine with placebo. Norwegian Arthritis Study Group.
Forre O.
Oslo Sanitetsforenings Rheumatism Hospital, Norway.
Arthritis Rheum. 1994 Oct;37(10):1506-12.
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Röntgenprogression bei früher rheumatoider Arthritis

Progression of joint damage in early active severe rheumatoid arthritis during 18 months of treatment: comparison of low-dose cyclosporin and parenteral gold.
Zeidler HK, Kvien TK, Hannonen P, Wollheim FA, Forre O, Geidel H, Hafstrom I, Kaltwasser JP, Leirisalo-Repo M, Manger B, Laasonen L, Markert ER, Prestele H, Kurki P.
Medizinische Hochschule Hannover, Division of Rheumatology, Germany.
Br J Rheumatol. 1998 Aug;37(8):874-82.
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Long term efficacy and safety of cyclosporin versus parenteral gold in early rheumatoid arthritis: a three year study of radiographic progression, renal function, and arterial hypertension.
Kvien TK, Zeidler HK, Hannonen P, Wollheim FA, Forre O, Hafstrom I, Kaltwasser JP, Leirisalo-Repo M, Manger B, Laasonen L, Prestele H, Kurki P.
Oslo City Department of Rheumatology, Diakonhjemmet Hospital, Oslo, Norway.  t.k.kvien(at)ioks.uio.no
Ann Rheum Dis. 2002 Jun;61(6):511-6
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Influence of cyclosporin A on radiological progression in early rheumatoid arthritis patients: a 42-month prospective study.
Drosos AA, Voulgari PV, Katsaraki A, Zikou AK.
Department of Internal Medicine, Medical School, University of Ioannina, Greece.
Rheumatol Int. 2000;19(3):113-8.
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Slow progression of joint damage in early rheumatoid arthritis treated with cyclosporin A.
Pasero G, Priolo F, Marubini E, Fantini F, Ferraccioli G, Magaro M, Marcolongo R, Oriente P, Pipitone V, Portioli I, Tirri G, Trotta F, Della Casa-Alberighi O.
Milan University, Italy. Arthritis Rheum. 1996 Jun;39(6):1006-15.
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Therapie der rheumatoiden Arthritis mit Immunosporin: Langfristige Wirksamkeit

Wirksamkeit, Sicherheit und Verträglichkeit von Ciclosporin bei der Langzeit-Therapie der rheumatoiden Arthritis

A study of the longterm efficacy and toxicity of cyclosporine A in rheumatoid arthritis.
Madhok R, Torley HI, Capell HA.
Centre for Rheumatic Diseases, University Department of Medicine, Glasgow Royal Infirmary, Scotland.
J Rheumatol. 1991 Oct;18(10):1485-9.
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The effectiveness and toxicity of cyclosporin A in rheumatoid arthritis: longitudinal analysis of a population-based registry.
Marra CA, Esdaile JM, Guh D, Fisher JH, Chalmers A, Anis AH.
Department of Health Care and Epidemiology, Faculty of Medicine, University of British Columbia, and Centre for Health Evaluation and Outcomes Sciences, St. Paul's Hospital, Vancouver, Canada.
Arthritis Rheum. 2001 Jun;45(3):240-5.
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